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Dosage/Direction for Use. oxacin hcl 500 mg Exacerbations of OA 7. oxacin hcl 500 mg 5 mg once daily, may be increased to 15 mg once daily RA 15 mg once daily, may be reduced to 7 5 mg daily High-risk patient Initially 7 5 mg once daily Patient w/ renal failure ≤7 5 mg once daily